While Nicks being out is a big big hurt hopefully Barden can fill in well, but obviously he wont see the soft coverage he did in Carolina. Hixon should see plenty of time in the slot as well.
That said with the secondary banged up Hosley's injury may be even worse. Hosley quietly became the front runner as the nickel in pre-season and then quietly took over as the starter even with prince back (albeit banged up) and did a very solid job. The kid has been very impressive. That all brings me to will hill who was very good in the pre-season and saw some time at the nickel himself. There is a good chance he plays there this Sunday. Will be interesting to see if he can step up and play the spot - althoughj i suppose they could turn to tryon (who fans are hating more and more these days) or coe if healthy. Still I think hill has a shot.
Again injuries are a part of the game and this is absolutely not to say that the giants can't and won't win without hosley, just saying he is more important then people may think. That also said the emergence of young secondary players like hill will be a huge help to accelerate their progression.
As usual get home and hit the qb early and often.