Individually? Absolutely not. I really don't see anyone else on the roster who is going to post 1000+ yards all by themselves whether it's receiving or rushing.
In a group effort? Probably. Eli will just have to spread the ball to more targets in the offense for the passing game and we'll need better production from the run game. We might not salvage all of Cruz's production but we would spread around at least 75% of it around imo.