Victor Cruz 99 yd TD against the Jets. Before the game, Rex Ryan made his "big brother" comments and there was a lot of media around his book in which he calls out the Giants and says the Jets will be the better team for the next decade. He then puts curtains up to cover the trophies outside the locker room. It is that play that IMO elevated the Giants to a Superbowl contender and send the Jets into the tailspin they are still plummeting down.
It also made their precious Cromartie look like an idiot.